Genetic Analysis Of Renal Function In An Isolated Australian Indigenous Community

In close consultation with the local land council, and with ethical approval from many ethics committees, we have performed a genome-wide association study (GWAS) on a sample cohort from the 1990s.
We also have a follow up data set of 120 study participants from 2014, with DNA sequence data.
I will discuss the statistical analyses of these data sets, with respect to issues of degraded DNA, high error rates and correlated samples.